Dynamic manipulation of functional plasticity of the host cell endosomal system by an intracellular pathogen (P08)

• Subject Area: Cell Biology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 467522186

This project will explore how Salmonella as a facultative intracellular pathogen triggers alterations in the endomembrane system of its host to promote its replication. The project will reveal how Salmonella effector proteins are targeted to endosomal membranes to exploit the functional plasticity of the mammalian endosomal system, with a focus on the lipid composition of Salmonella-containing vacuoles (SCV). This analysis will reveal how Salmonella controls the biogenesis of its intracellular niche.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1557: Functional Plasticity encoded by Cellular Membrane Networks
• Applicant Institution: Universität Osnabrück
• Project Head: Professor Dr. Michael Hensel