Plasticity of cellular lipid handling machineries in metabolic adaptation (P03)

• Subject Area: Cell Biology ; Biochemistry
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 467522186

This project takes a broad approach to identify principles controlling the functional plasticity of lipid exchange at membrane contact sites, including lipid droplets, with a primary focus on sterols and storage lipids. Based on a microscopy-based screen, the dynamic membrane localization of lipid handling factors will be analyzed under different metabolic conditions. Targeting and metabolic control of factors such as the DAG acyltransferase Dga1 will be analyzed in detail to understand their metabolic control and ER-membrane localization.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1557: Functional Plasticity encoded by Cellular Membrane Networks
• Applicant Institution: Universität Osnabrück
• Project Head: Professorin Dr. Maria Bohnert