Perinatal development of dermal macrophage diversity (B03)

• Subject Area: Immunology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 491676693

B03 will combine lineage tracing of highly-dedicated dermal Mφ with proficiency in single cell epigenomics. The project explores factors driving perinatal development of dermal Mφ diversity with a focus on 1) identification of novel Mφ niches in the dermis, 2) perinatal competition between fetal and bone-marrow-derived cells for immunological niches in the dermis, 3) limits of and cues for dermal Mφ subset plasticity. Single-cell transcriptomics and epigenomics, fate mapping, and high-resolution tissue imaging will be employed. Including B03 will enable the consortium to profit from expert knowledge in these technologies.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 359: Perinatal Development of Immune Cell Topology
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Heads: Dr. Julia Kolter; Dr. Sebastian Preißl