Perinatal fate decisions of macrophages in protected tissues (B01)

• Subject Area: Immunology ; Medical Microbiology and Mycology, Hygiene, Molecular Infection Biology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 491676693

B01 will expand Mr. professor work on myeloid cell development starting in embryonic life by delineating patterns of ontogeny, underlying transcriptional programs and molecular signals driving the perinatal development of parenchymal (pMφ) as opposed to perivascular Mφ (periMφ). The project focuses on tissues that are largely protected from direct microbial contact (brain, heart, kidney) and exploits novel fate mapping systems, single-cell profiling and cell-specific mutants to define pre- to postnatal check points, tissue-specific niches and cues that modify the fate and function of pMφ and periMφ. PILOT will benefit from Mr. professor groundbreaking discoveries and expertise in myeloid fate mapping and cell lineage tracing

• DFG Programme: CRC/Transregios
• Subproject of: TRR 359: Perinatal Development of Immune Cell Topology
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professor Dr. Marco Prinz