Perinatal crosstalk of microbiota and intestinal macrophages in the control of mucosal pathogens
(A06)
Subject Area
Immunology
Medical Microbiology and Mycology, Hygiene, Molecular Infection Biology
Term
since 2023
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 491676693
A06 will explore the co-development of the neonatal microbiota and intestinal Mφ, focusing on metabolic programming and epigenetic imprinting in the integration of potentially highly pathogenic mucosal colonizers, in particular streptococci, into the host-adapted microbiota. Molecular and cellular mechanisms underlying co-evolution of a stable intestinal host-microbe interface will be explored. A06 commands specific knowledge in perinatal bacterial colonization and infection models and microbiota analysis, which will be instrumental for other PILOT projects studying the developing host-microbe interface.
DFG Programme
CRC/Transregios
