The role of S100-alarmins in the perinatal development of respiratory immunity (A03)

• Subject Area: Immunology ; Developmental Biology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 491676693

The project leaders previously found that S100-alarmins are endogenous factors that tune systemic and gut immunity after birth, thereby ensuring immune adaptation to the environment. A03 will explore S100A8/A9 in the perinatal development of lung and airway immunity, with a focus on neonatal and long-term programming of epithelial cells and cross-talk with professional immune cells, platelets and the vascular system. A03 will also elucidate the cellular source of S100A8/A9 in the amniotic fluid by investigating non-immune cells in the lung. A03 contributes elaborate tools for steering immunity and analyzing its regulation in neonatal mice and newborn infants with an explicit translational focus.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 359: Perinatal Development of Immune Cell Topology
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Heads: Privatdozent Dr. Konstantin Stark; Professorin Dr. Dorothee Viemann