Uncovering host mechanisms underlying Salmonella persistent infection of intestinal epithelial cells (B05)

• Subject Area: Medical Microbiology and Mycology, Hygiene, Molecular Infection Biology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 492620490

B05 hypothesises that some host cell subtypes in the mucosal layer are vulnerable and lack essential restriction factors to control bacterial expansion. B05 proposes to identify the molecular pathways underlying the host cell mechanisms underlying Salmonella transition from the ‘Salmonella containing vacuole’ to the cytosol. For this purpose, B05 will combine human organoid intestinal epithelial cells and temporal single-cell genomics. If successful, this project will lead to new interception strategies that inhibit bacterial hyper-replication in the intestinal tract and restrict persistent infections.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1583: Decisions in Infectious Diseases (DECIDE)
• Applicant Institution: Julius-Maximilians-Universität Würzburg
• Project Head: Professor Dr. Antoine-Emmanuel Saliba