A07 will assess the role of type I and III interferons, NF-kB and protein kinase R activation, as well as cell-cell communication in local herpes virus control. Based on differences in the viral gene products identified in different experimental conditions, A07 will identify key host determinants of local infection control. A long-term goal is to provide a mechanistic understanding of decision points for spatial and time-resolved immune control of genital herpes and the role of viral countermeasures thereof.
DFG Programme
Collaborative Research Centres
