Project Details
Projekt
Epithelial physiology and immune status as decision points in the initiation of toxin-induced Clostridioides difficile colitis (A04)
Subject Area
Medical Microbiology and Mycology, Hygiene, Molecular Infection Biology
Term
since 2023
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 492620490
By combining classic microbiological techniques, biochemical and imaging assays with transcriptomics, metabolomics, and drug-based host perturbation experiments, A04 will unravel how Bacteroides thetaiotaomicron modulates epithelial immune responses to Clostridioides difficile toxins at multiple levels. This strategy will identify novel molecular decision points to develop urgently needed, host-centric intervention strategies against C. difficile infections.
DFG Programme
Collaborative Research Centres
Subproject of
SFB 1583:
Decisions in Infectious Diseases (DECIDE)
Applicant Institution
Julius-Maximilians-Universität Würzburg
