Project Details
SFB 1665: Sexdiversity - Determinants, meanings and implications of sex diversity in sociocultural, medical and biological landscapes
Subject Area
Medicine
Biology
Humanities
Social and Behavioural Sciences
Biology
Humanities
Social and Behavioural Sciences
Term
since 2024
Website
Homepage
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 515637292
The categorisation of sex and the relationship between sex and gender are among the most controversial aspects of our understanding of the human body. Recently there has been substantial criticism by both the humanities and the biological sciences of an exclusively binary and essentialising model of sex. Thus, a starting point for new research is the observation that sex is multi-layered, dynamic, and in need of context-dependent reference frames. In this CRC, we aim to define the diversity of sex in different research contexts. In the different layers of analysis – from cells to organs, from organisms to societies – and by characterising the determinants, meanings and implications of sex at each of these levels, we will specify what “sex” refers to. The CRC will enable us to address the central hypothesis that sex is diverse and manifests itself through context-dependent differences that emerge on multiple levels. We will use cutting-edge methodology from the natural sciences, the humanities and social sciences to generate new insights into the biology of sex diversification, the impacts of (biological) sex and (socio-cultural) gender norms on clinical practice and biomedical research, and the sociocultural formation of sex categories. The CRC brings together scholars, researchers and clinicians from the Universität zu Lübeck with strong expertise in their respective fields, and who have already collaborated on fundamental, translational and clinical aspects of sex-related research. They are complemented by experts from the Christian-Albrechts-Universität zu Kiel, with whom long-standing scientific and clinical collaborations exist. They are further complemented by selected external experts from Berlin, Flensburg, Magdeburg, Munich and Hannover with specific expertise in DSD research, gender studies and the legal aspects of sex diversity. The CRC will be organised in a way that stimulates interdisciplinary work between biological sciences, medicine, humanities and social sciences. Collaboratively, we will develop new research questions and understandings of sex diversity, and involve stakeholders and societal actors in the research process, thereby generating transdisciplinary impact. With the CRC, we hope to change the way sex is considered as a research variable in biomedical research and basic science by providing definitions and reference frames for sex which are contextual and adequate for its complexity and multi-layered nature. This will lead to more accurate and differentiated understanding of sex and sex diversity and thereby provide a solid basis for personalised medicine. The contribution of the humanities and social sciences will be to deepen the understanding of the interaction of sex and gender, and support methodological reflexivity. The findings of the CRC will elucidate the determinants, meanings and implications of sex and sex diversity, which is of utmost societal relevance and at the very core of our self-concept as humans.
DFG Programme
Collaborative Research Centres
Current projects
- M01 - The single cell transcriptional and chromatin landscape of sex differentiation and the role of the androgen pathway in extra-genital somatic tissues (Project Heads Holterhus, Paul-Martin ; Spielmann, Malte )
- M02 - Programming of transcriptional identity in response to oestrogens and androgens in developing human brain cells (Project Heads Hornig, Nadine ; Müller, Franz-Josef )
- M03 - Cardiovascular and metabolic properties, gonadal functions and steroid metabolism in mice lacking the androgen receptor or androgen production (Project Heads Frielitz-Wagner, Isabel Viola ; Mittag, Jens )
- M04 - Identification of novel structural and non-coding variants associated with differences of sex development (Project Heads Hiort, Olaf ; Kircher, Martin )
- M05 - Describing the metabolome of sex variability (Project Head Seeger, Karsten )
- M06 - The atlas of steroid hormones in human genital tissues by simultaneous determination of the delta-5, alternative, backdoor and 11-oxygenated C-19 metabolites (Project Heads Holterhus, Paul-Martin ; Kulle, Alexandra )
- M07 - Multi-omics analysis of sex variability (Project Head Busch, Hauke )
- M08 - Overcoming the binary of sex in genetic studies (Project Head Aherrahrou, Ph.D., Redouane )
- S01 - Impact of steroid hormones on brain networks of affective behaviour (Project Heads Krämer, Ulrike M. ; Reisch, Nicole )
- S02 - Diversity of sex-related mortality and outcome in preterm infants and neonates (Project Heads Göpel, Wolfgang ; Koenig, Inke Regina )
- S03 - Obesity as a model of sex diversity in steroid metabolism (Project Heads Frielitz-Wagner, Isabel Viola ; Laudes, Matthias )
- S04 - Sex/Gender knowledge in transition? The individual meaning of sex/gender and ‘doing gender’ in the context of the introduction of a legal third sex/gender option (Project Head Jürgensen, Martina )
- S05 - Normative implications of human rights of persons with DSD in a non-binary legal world (Project Heads Mangold, Anna Katharina ; Rehmann-Sutter, Christoph )
- S06 - “Bringing gender into science – and back!” Historical and ethnographic perspectives on sex development research (Project Heads Stammberger, Birgit ; Stoff, Heiko )
- S07 - “The third option”. On the emergence of the category “divers” as a recognized societal reality between intersex* activism, life sciences, jurisprudence, ethics and gender theory (Project Head Palm, Kerstin )
- S08 - The diverse psyche in therapy: Sex/gender knowledge in West German psychotherapy (1960-2020) (Project Heads Malich, Lisa ; Palm, Kerstin )
- S09 - Medicating sex: Medico-historical perspectives on hormone products, patient experiences, and the science and practice of sex diversity, c. 1950-1990 (Project Head Nemec, Birgit )
- Z01 - CRC governance, mutual learning and coordination – central administrative project (Project Head Hiort, Olaf )
- Z02 - Differences of sex development – Providing access to health research (Project Head Hiort, Olaf )
- Z03 - Data management and bioinformatics (Project Head Busch, Hauke )
- Z04 - Integrated Research Training Group (Project Heads Hundt, Jennifer ; Krämer, Ulrike M. ; Stammberger, Birgit )
- Z05 - Diversity of sex in public outreach and science communication (Project Heads Kohlrausch, Jonathan ; Malich, Lisa ; Rehmann-Sutter, Christoph )
Applicant Institution
Universität zu Lübeck
Participating Institution
Charité - Universitätsmedizin Berlin
Participating University
Christian-Albrechts-Universität zu Kiel; Europa-Universität Flensburg; Humboldt-Universität zu Berlin; Ludwig-Maximilians-Universität München; Medizinische Hochschule Hannover; Otto-von-Guericke-Universität Magdeburg
Spokesperson
Professor Dr. Olaf Hiort