Immunsuppression durch Nukleosidanaloga in der HIV-Therapie - Therapeutische Beeinflussbarkeit durch Uridin

• Applicant: Professor Dr. Ulrich A. Walker
• Subject Area: Rheumatology
• Term: from 1998 to 2009
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5153120

• Final Report Year: 2009

Final Report Abstract

No abstract available

Publications

• Pyrimidine nucleoside depletion sensitizes to and is a consequence of the mitochondrial hepatotoxicity of the reverse transcriptase inhibitor stavudine. Am J Pathol. (2008) 172:681-90
  B. Setzer, D. Lebrecht and UA. Walker
  
• Uridine supplementation antagonizes zidovudine-induced mitochondrial myopathy and hyperlactatemia. Arthritis Rheum. (2008) 58:318-326
  D. Lebrecht, C. Deveaud, B. Beauvoit, J. Bonnet, J. Kirschner and UA. Walker
  
• Mitochondrial tubulopathy in tenofovir-DF treated rats. JAIDS (2009) 51:258-263
  D. Lebrecht, AC. Venhoff, J. Kirschner, T. Wiech, N. Venhoff and UA. Walker
  
• Uridine supplementation with Mitocnol attenuates the peripheral neuropathy and encephalopathy induced by antiretroviral nucleoside analogues. AIDS (2009)
  N. Venhoff, C. Deveaud, B. Beauvoit, J. Bonnet, AC. Venhoff, K. Müller, J. Kirschner, D. Lebrecht and UA. Walker