Regulation des Stickstoffmetabolismus in Bacillus subtilis durch den Repressor CcpA - den zentralen Faktor der C-Katabolitenrepression

• Antragsteller: Professor Dr. Jörg Stülke
• Fachliche Zuordnung: Stoffwechselphysiologie, Biochemie und Genetik der Mikroorganismen
• Förderung: Förderung von 2002 bis 2009
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5126462

• Erstellungsjahr: 2009

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• (2003) Ammonium utilization in Bacillus subtilis: transport and regulatory functions of NrgA and NrgB. Microbiology 149: 3289-3297
  Detsch, C. & Stülke, J.
  
• (2003) Positive regulation of gene expression by the catabolite control protein CcpA in Bacillus subtilis. In: Regulatory Networks in Prokaryotes. Dürre, P., and Friedrich, B. (eds.) Norfolk: Horizon Scientific Press, pp. 181-186
  Ludwig, H., Blencke, H.-M., Schmalisch, M., Detsch, C., Merzbacher, M. & Stülke, J.
  
• (2003) The regulatory link between carbon and nitrogen metabolism in Bacillus subtilis: regulation of the gltAB operon by the catabolite control protein CcpA. Microbiology 149: 3001- 3009
  Wacker, I., Ludwig, H., Reif, I., Blencke, H.-M., Detsch, C. & Stülke, J.
  
• (2003) Transcriptional profiling of gene expression in response to glucose in Bacillus subtilis: regulation of the central metabolic pathways. Metab. Engn. 5: 133-149
  Blencke, H.-M., Homuth, G., Ludwig, H., Mäder, U., Hecker, M. & Stülke, J.
  
• (2006) Interaction of the membrane-bound GlnK-AmtB complex with the master regulator of nitrogen metabolism TnrA in Bacillus subtilis. J. Biol. Chem. 281: 34909-34917
  Heinrich, A., Woyda, K., Brauburger, K., Meiss, G., Detsch, C., Stülke, J. & Forchhammer, K.
  
• (2006) Regulation of citB expression in Bacillus subtilis: Integration of multiple metabolic signals in the citrate pool and by the general nitrogen regulatory system. Arch. Microbiol. 185: 136-146
  Blencke, H.-M.. Reif, I., Commichau, F. M., Detsch, C, Wacker, I., Ludwig, H. & Stülke, J.
  
• (2006) Regulatory links between carbon and nitrogen metabolisms. Curr. Opin. Microbiol. 6:167-172
  Commichau, F. M., Forchhammer, K. & Stülke, J.
  
• (2007) A regulatory protein-protein interaction governs glutamate biosynthesis in Bacillus subtilis: The glutamate dehydrogenase RocG moonlights in controlling the transcription factor GltC. Mol. Microbiol. 65: 642-654
  Commichau, F. M., Herzberg, C., Tripal. P., Valerius, O. & Stülke, J.
  
• (2007) Characterization of Bacillus subtilis mutants with carbon-source independent glutamate biosynthesis. J. Mol. Microbiol. Biotechnol. 12:106-113
  Commichau, F. M., Wacker, I., Schleider, J.. Blencke, H. M., Reif, I., Tripal, P. & Stülke, J.
  
• (2007) SPINE: A method for the rapid detection and analysis of protein-protein interactions in vivo. Proteomics 7: 4032-4035
  Herzberg, C., Florez Weidinger, L. A., Dörrbecker, B., Hübner, S., Stülke, J. & Commichau, F. M.
  
• (2007) Transcriptional and metabolic responses of Bacillus subtilis to the availability of organic acids: Transcription regulation is important but not sufficient to account for metabolic adaptation. Appl. Env. Microbiol. 73: 499-507
  Schilling, O., Frick, 0., Herzberg, C, Ehrenreich, A., Heinzle, E., Wittmann, C. & Stülke, J.
  
• (2008) Carbon catabolite repression in bacteria: many ways to make most out of nutrients. Nature Rev. Microbiol. 6: 613-624
  Görke, B. & Stülke, J.
  
• (2008) Glutamate metabolism in Bacillus subtilis: Gene expression and enzyme activities evolved to avoid futile cycles and to allow rapid responses to perturbations in the system. J. Bacteriol. 190: 3557-3564
  Commichau, F. M., Gunka, K., Landmann, J. J. & Stülke, J.
  
• (2008) Trigger enzymes: bifunctional proteins active in metabolism and in controlling gene expression. Mol. Microbiol. 67:692-702
  Commichau, F. M. & Stülke, J.
  
• (2009) Novel activities of glycolytic enzymes in Bacillus subtilis: Interactions with essential proteins involved in mRNA processing. Mol. Cell. Proteomics
  Commichau, F. M., Rothe, F. M., Herzberg, C., Wagner, E., Hellwig, D., Lehnik-Habrink, M., Hammer, E., Völker, U. & Stülke, J.