Aerosol-assisted synthesis of spherical mesoporous CeO2 parTicles as smart nAnoCarriers for theranosTIC

• Applicant: Professor Dr. Alfred Weber
• Subject Area: Mechanical Process Engineering ; Biological Process Engineering
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 505888839

Nowadays, we are faced with the issue that conventional drug delivery systems must be administered systematically in high doses and tend to cause severe side-effects because of the nonspecific uptake of drugs by healthy tissues/organs. In this work, an easily controllable aerosol-based approach is proposed to produce biocompatible, mesoporous cerium oxide particle with well-controlled internal morphology and shell porosity for controlling the drug loading and release properties. Moreover, in order to have a specific release we will chemically modify these particles with modified polysaccharides (elaboration of stimuli-responsive systems). The ultimate goal of our project is to propose a theranostic platform capable of assessing diseased cells and able to deliver therapeutic molecules in a controllable way.

• DFG Programme: Research Grants
• International Connection: France
• Partner Organisation: Agence Nationale de la Recherche / The French National Research Agency
• Cooperation Partner: Professorin Dr. Sabrina Belbekhouche