Phagocytic crosstalk between neutrophils and macrophages in rheumatoid arthritis (C05)

• Subject Area: Immunology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 449437943

During the inflammatory response in Rheumatoid Arthritis (RA), neutrophils show targeted migration towards distinct anatomical niches, such as the synovial cavity and the synovial fat pad, also populated by heterogeneous macrophage populations. There, neutrophils undergo different cell death modalities, apoptosis and NETosis. We hypothesize that neutrophil subpopulations individually drive RA pathogenesis through their clearance by macrophages. Hence, our studies will provide valuable information on neutrophil-driven macrophage inflammatory responses, focusing on the effects of neutrophil cell death in macrophages.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 332: Neutrophils: origin, fate and function
• Applicant Institution: Universität Münster
• Participating Institution: Leibniz-Institut für Analytische Wissenschaften -ISAS- e.V.
• Project Heads: Dr. Noelia Alonso Gonzalez, since 7/2022; Professorin Dr. Anika Grüneboom, since 7/2022