The role of KV1.3 on Ca2+ signalling and neutrophil effector functions (C02)

• Subject Area: Immunology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 449437943

Neutrophils play a critical role during the inflammatory response. Recent studies have demonstrated that loss of the voltage-gated potassium channel KV1.3 impairs sustained calcium signalling during neutrophil activation leading to impaired phagocytosis and neutrophil adhesion. Here we aim to dissect the exact role of KV1.3 in neutrophil functionality with specific focus on neutrophil recruitment, NET release and inflammasome activation.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 332: Neutrophils: origin, fate and function
• Applicant Institution: Universität Münster
• Project Head: Professor Dr. Markus Sperandio, since 7/2022