Molecular pathways underlying neutrophil diversity remain ill-defined. In this project we will follow the hypothesis that mechanisms of innate immune memory prime the functional phenotype of neutrophils regarding their subsequent response patterns; a process which may be relevant during development of myeloid stem cells as well as during repetitive stimulation of mature (sub)-populations of neutrophils. The long-term goal of our project is the targeted manipulation of innate immune memory mechanisms in neutrophils for treatment of inflammatory diseases.
DFG Programme
CRC/Transregios
