Neutrophil modulation during cerebral ischemia by the nuclear receptor NR4A1 (B02)

• Subject Area: Immunology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 449437943

Sterile inflammation upon cerebral ischemia is accompanied by immune cell infiltration. Neutrophils exert a crucial role within the inflammatory response and finally on neuronal damage via interaction with other immune cells of the innate and adaptive immune system. However, unselective blockade of brain neutrophil infiltration has so far been unsuccessful in clinical studies. We hypothesize that neutrophils are differentially modulated in the context of stroke, that the nuclear receptor NR4A1 is critically involved and that pharmacological modulation of NR4A1 opens the possibility of a fine-tuned therapeutic intervention.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 332: Neutrophils: origin, fate and function
• Applicant Institution: Universität Münster
• Project Heads: Professorin Dr. Luisa Klotz, since 7/2022; Professor Dr. Jens Minnerup, since 7/2022