Macrophage regulation of neutrophil phenotype and function (A06)

• Subject Area: Immunology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 449437943

Neutrophils are potent effector cells and therefore require precise regulation. Within organs, they quickly adopt tissue-dependent properties to serve specific physiological needs. Because neutrophils and macrophages frequently interact, we hypothesize that tissue-resident macrophages modulate neutrophil properties. Here, we will determine the impact of tissue macrophages on neutrophil phenotypes and functions, and characterize the potential role of the developmental origin of macrophages therein. Further, we will analyse the importance of macrophages for shaping neutrophil properties in a model of cardiac injury.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 332: Neutrophils: origin, fate and function
• Applicant Institution: Universität Münster
• Project Head: Professor Dr. Christian Schulz, since 7/2022