Impact of type I interferons on tumour-dependent granulopoiesis and neutrophil tumourigenicity (A05)

• Subject Area: Immunology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 449437943

The aim of this proposal is to unravel the role of IFN receptor (IFNAR1) in the development of tumour-associated neutrophils. As lack of IFNAR1 leads to pro-tumour activity of neutrophils and as IFNAR1 expression is significantly downregulated in the tumour microenvironment, we hypothesize that the tumour actively disturbs IFNAR1 signalling to support the development of pro-tumour neutrophils. Bearing this in mind, we aim to identify the molecular mechanisms involved in the development of neutrophils in IFNAR1 deficiency, thus potentially identifying novel therapeutic targets that allow to reverse the pro-tumour bias of neutrophils.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 332: Neutrophils: origin, fate and function
• Applicant Institution: Universität Münster
• Project Heads: Dr. Anja Hasenberg, since 7/2022; Professorin Dr. Jadwiga Jablonska-Koch, since 7/2022