Identification of a molecular signature that influences neutrophil migration and function in urinary tract infection during chronic lymphocytic leukaemia (A03)

• Subject Area: Immunology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 449437943

Neutrophils are very important leukocytes for the acute control of urinary tract infection (UTI). However, patients that suffer from chronic lymphocytic leukaemia (CLL) are highly susceptible to bacterial infection, such as UTI. Here, we will use models that combine CLL and UTI and will evaluate molecules that affect neutrophil migration and function and predispose to severe bacterial infections in CLL.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 332: Neutrophils: origin, fate and function
• Applicant Institution: Universität Münster
• Project Head: Professor Dr. Daniel Robert Engel, since 7/2022