The aim of the present proposal is to unravel the importance of the vascular periphery – over and above processes occurring in the bone marrow – as site of end-stage neutrophil maturation. Given tremendous proteomic and transcriptomic difference in mature bone marrow and circulating neutrophils, we hypothesize that neutrophils undergo final stages of maturation in the periphery. Successfully addressing these aims would provide an innovative paradigm to understanding neutrophil biology as it will establish peripheral vascular beds as a novel (possibly disease generating) component during neutrophil maturation.
DFG Programme
CRC/Transregios
