Vascular damage control by deubiquitinases (A07)

Endothelial cells (ECs) are long-lived cells that rely on conserved stress response pathways to preserve cellular integrity in adverse environmental conditions. These pathways are particularly important during tissue revascularization, where ECs encounter diverse stresses such as nutrient and oxygen deprivation. But how ECs surveil, adapt to and shut off stress signalling is poorly understood. Here we will study the role of deubiquitinases (DUBs) in these processes focussing on models of tissue hypoxia and ischemia. We hypothesize that DUBs are essential components of stress-induced signalling networks, which cooperatively protect ECs against acute damage.

DFG Programme Collaborative Research Centres

Subproject of SFB 1531:  Damage control by the stroma-vascular compartment

Applicant Institution Goethe-Universität Frankfurt am Main

Project Heads Professor Dr. Ivan Dikic; Professor Dr. Michael Potente