Metabolic control of the epigenetic landscape (C08*)

• Subject Area: Biochemistry
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 325871075

Dynamics in the epigenetic landscape fully rely on the availability metabolites that serve as co-substrates for epigenetic enzymes. In our proposed project, we want to do a comprehensive multi-omics based analysis of the metabolic-epigenetic interplay in haematopoietic and leukemic cells. The haematopoietic system serves as an ideal model to study the metabolic-epigenetic interplay as differentiation from haematopoietic stem cells to mature and functional blood cells, which is accompanied by drastic epigenetic changes, happens throughout lifespan and failures to establish the correct epigenetic pattern can result in formation of leukemic cells at any step of the process.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1309: Chemical Biology of Epigenetic Modifications
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Head: Professorin Dr. Franziska Traube