Aromatic foldamer-based molecular tools for interference with and investigation of epigenetic proteins (C07*)

• Subject Area: Biological and Biomimetic Chemistry
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 325871075

The project aims to deliver aromatic oligoamide foldamer-based ligands able to interfere with proteins relevant to chromatin structure and chromatin epigenetic modifications. In a first approach, foldamers able to mimic the shape and charge surface properties of B-DNA will be designed and synthesized to disrupt protein-nucleic acid interactions. In a second approach, mRNA display selection will be used to identify foldamer-peptide macrocycles that selectively bind epigenetic targets. The structural basis of foldamer-protein interactions will be investigated. The foldamers’ bioavailability will be subsequently improved.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1309: Chemical Biology of Epigenetic Modifications
• Major Instrumentation: Peptid-Synthesiser (teilfinanziert)
• Instrumentation Group: 3180 Peptid-, Protein-Sequenzer
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Head: Professor Dr. Ivan Huc