The role of TRPP2 in the pathogenesis of polycystic kidney disease and primary cilia signaling (P25*)

• Subject Area: Pharmacology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 239283807

Together with Polycystin-1, TRPP2, also known as Polycystin-2, forms Ca2+-permeable cation channels in the primary cilium, a central signaling micro-compartment of the cell. Defects in TRPP2 cause polycystic kidney disease, which is ameliorated when cilia are ablated in mouse models of polycystic kidney disease. This suggests that TRPP2 mediates a cystogenic signaling pathway in primary cilia, the nature of which is still unknown. In this project, we aim to reveal and dissect this cystogenic ciliary signaling pathway by time-resolved cilia proteomics. As specific elevation of cAMP in cilia leads to cyst formation in vitro, we will explore the relation between ciliary cAMP signaling and TRPP2-dependent cilia signaling processes.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 152: TRiPs to Homeostasis: Maintenance of Body Homeostasis by Transient Receptor Potential Channel Modules
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Head: Professor Dr. David Mick