Project Details
Projekt
Impact of purinergic signaling on epithelial cell-adipocyte crosstalk in intestinal inflammation and fibrosis in Crohn’s Disease (A19*)
Subject Area
Cell Biology
Term
since 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 335447717
In Crohn’s disease (CD) highly inflamed intestinal segments are enveloped by hyperplastic, fibrotic ‘creeping fat’ providing direct contact between adipocytes (AC) and mucosal epithelial cells (EC). The processes driving the formation of creeping fat and its role for inflammation are poorly understood and our preliminary data suggest that purinergic signaling pathways are affected. Using 3D in vitro organoid models derived from CD patients and controls we aim to unravel the role of adenine nucleotide release, processing and sensing for the crosstalk between intestinal EC and AC and intestinal inflammation and fibrosis.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität Hamburg
Project Heads
Professorin Madeleine Bunders, Ph.D.; Dr. Anna Worthmann
