Structural basis of complex I function and assembly
(P14)
Subject Area
Biochemistry
Term
since 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 450648163
Respiratory complex I is a 1 MDa membrane protein complex with a central role in mitochondrial energy metabolism. Although the structure of complex I has been determined at high resolution, the mechanism of redox-coupled proton translocation remains controversial. In project P14, our goal is to elucidate the catalytic cycle and to understand the biogenesis of the intricate multi protein complex in molecular detail.
DFG Programme
Collaborative Research Centres
