Structural basis of complex I function and assembly (P14)

Subject Area Biochemistry
Term since 2022
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 450648163
 

Project Description

Respiratory complex I is a 1 MDa membrane protein complex with a central role in mitochondrial energy metabolism. Although the structure of complex I has been determined at high resolution, the mechanism of redox-coupled proton translocation remains controversial. In project P14, our goal is to elucidate the catalytic cycle and to understand the biogenesis of the intricate multi protein complex in molecular detail.
DFG Programme Collaborative Research Centres
Subproject of SFB 1507:  Protein Assemblies and Machineries in Cell Membranes
Applicant Institution Goethe-Universität Frankfurt am Main
Project Heads Dr. Janet Vonck; Professor Dr. Volker Zickermann