Modulation of tyrosine receptor signaling investigated by NMR spectroscopy (P10)

Subject Area Structural Biology
Term since 2022
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 450648163
 

Project Description

The central aim of project P10 is to investigate fundamental aspects of tyrosine kinase receptor signaling pathways for two pharmacological relevant receptors (FGFR and EPH) and their respective ligands. The dynamics of receptor/ligand interaction and the influence of inhibitors of low molecular weight will be investigated, using several biophysical and structural biology techniques, in particular NMR spectroscopy, available within CRC 1507.
DFG Programme Collaborative Research Centres
Subproject of SFB 1507:  Protein Assemblies and Machineries in Cell Membranes
Applicant Institution Goethe-Universität Frankfurt am Main
Project Head Professor Dr. Harald Schwalbe