Project Details
Projekt
Role of mTORC1 and protein translation in memory consolidation in the neocortex (A10*)
Subject Area
Experimental and Theoretical Network Neuroscience
Term
since 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 327654276
Medial-temporal lobe (MTL) input to layer 1 (L1) of the neocortex is crucial for memory consolidation. Based on our own preliminary data we hypothesize that protein synthesis and upstream mTORC1 activity are required for MTL-dependent plasticity and therefore underlie learning in the neocortex. We will test this hypothesis by combining genetic and pharmacological manipulations with biochemical and cell biological approaches to study the impact of altered protein synthesis or mTORC1 activity on MTL-gated memory consolidation. Specifically, we will investigate the reliance of MTL-gated memory consolidation on local mTORC1-regulated protein synthesis in the tuft dendrites of layer 5 (L5) pyramidal neurons or in somatostatin-positive interneurons. Moreover, we will examine the molecular events that are induced by an enriched environment (EE) known to facilitate learning and memory consolidation. We expect these studies to provide insights into the molecular mechanisms for memory formation and consolidation in a defined behavioral paradigm and location.
DFG Programme
Collaborative Research Centres
Subproject of
SFB 1315:
Mechanisms and disturbances in memory consolidation: From synapses to systems
Applicant Institution
Humboldt-Universität zu Berlin
