Serial prospective multimodal imaging of the lymphatic organs and myocardium to predict cardiac function and remodelling in patients after myocardial infarction (C02)

Subject Area Cardiology, Angiology
Term since 2022
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 453989101
 

Project Description

We are conducting a prospective clinical study using multimodal imaging to monitor chemokine receptor 4 (CXCR4) expression in the lymph nodes, myocardium, spleen, and bone marrow after acute MI. The combination of cardiac magnetic resonance (CMR), echocardiography, and positron emission tomography (PET) along with blood collection for immunophenotyping will allow us to determine i) if the size of mediastinal lymph nodes and their respective PET-derived CXCR4 signals at baseline correlate with the adaptive immune response to acute cardiac injury; and ii) if they predict cardiac adverse remodelling during longitudinal fo low-up.
DFG Programme Collaborative Research Centres
Subproject of SFB 1525:  Cardio-Immune Interfaces
Applicant Institution Julius-Maximilians-Universität Würzburg
Project Heads Dr. Theresa Wei-yi Laetitia Reiter; Professor Dr. Rudolf Werner