Impact of nuclear ERK 1/2 signalling in inflammation-driven cardiovascular diseases (B03)

Subject Area Cardiology, Angiology
Term since 2022
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 453989101
 

Project Description

ERK1/2 signalling has broad implications for many cardiovascular diseases. Preliminary data suggest that an autophosphorylation of ERK1/2 influences the function of antigen presenting cells and T cells. This ERK modification may help to predict/dissect the risk of heart failure and to direct ERK1/2 intervention strategies towards improved outcomes. Therefore, the project aims to understand the role of protective and maladaptive signaling of ERK1/2 in leukocytes in models of ischemic- and non-ischemic cardiomyopathies.
DFG Programme Collaborative Research Centres
Subproject of SFB 1525:  Cardio-Immune Interfaces
Applicant Institution Julius-Maximilians-Universität Würzburg
Project Heads Professorin Dr. Kristina Lorenz; Professorin Dr. Alma Zernecke-Madsen