Role of β2-adrenergic- and natriuretic peptide receptor- induced signalling in CD4+ T-cells after myocardial infarction (B01)

Subject Area Cardiology, Angiology
Cell Biology
Term since 2022
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 453989101
 

Project Description

The project aims to understand how adrenergic and natriuretic peptide signalling contributes to T-cell responses during myocardial infarction (MI). Genetic manipulation of these pathways and adoptive cell trans- fer experiments will be employed in a mouse model of MI. Our results can shed light on the neuroendocrine regulation of T-cells within the infarcted milieu.
DFG Programme Collaborative Research Centres
Subproject of SFB 1525:  Cardio-Immune Interfaces
Applicant Institution Julius-Maximilians-Universität Würzburg
Project Heads Professor Dr. Stefan Frantz; Professor Dr. Viacheslav Nikolaev