Pathomechanisms of Immunosenescence in the post-myocardial infarction healing response
(A03)
Subject Area
Cardiology, Angiology
Term
since 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 453989101
The prevalence of myocardial diseases increases sharply with age, but most preclinical research in cardiology is conducted in young, healthy animals. Aging is accompanied by accumulating effector T-cells with an inflammatory phenotype that can affect the post-myocardial infarction (MI) healing process. Herein, we will employ several experimental in vivo models to dissect the mechanisms through which immune status al- terations associated with aging, and particularly T-cell immunosenescence, impact the post-MI outcome and the progression of ischemic heart failure.
DFG Programme
Collaborative Research Centres
