Paracrine fibroblast growth factors as metabolic messengers between adipose tissue cells
(P09)
Subject Area
Cell Biology
Anatomy and Physiology
Endocrinology, Diabetology, Metabolism
Term
since 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 450149205
The presence of thermogenic uncoupling protein 1 (UCP1) is thought to be a unique feature of fully differentiated brown adipocytes. Several paracrine fibroblast growth factors (FGF) induce the expression of UCP1 in undifferentiated preadipocytes. In this project, we aim to determine the specific FGF dominantly constituting this signaling axis in vivo, identify the origin of this factor and thus decipher all components of this novel intra-organ adipose tissue signaling network. We will further employ UCP1-expressing preadipocytes as a novel model in which to study the potency of UCP1 interacting proteins.
DFG Programme
CRC/Transregios
