Metabolic regulation through the aryl hydrocarbon receptor repressor (AhRR) via immune cell/adipocyte interactions
(P08)
Subject Area
Endocrinology, Diabetology, Metabolism
Immunology
Term
since 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 450149205
The Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor, regulated by the AhR Repressor (AhRR). We have discovered that myeloid cell-specific AhRR-deficient mice are protected from diet-induced obesity and feature signs of browning. In this project, we want to investigate the influence of the AhRR on the interaction of immune cells with brown/beige adipocytes to ultimately identify AhRR-dependent mediators regulating thermogenesis.
DFG Programme
CRC/Transregios
