Regulation of energy metabolism in brown fat through lipid uptake and lipid processing in adipose tissue macrophages (P07)

• Subject Area: Immunology ; Endocrinology, Diabetology, Metabolism
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 450149205

Together with adipocytes, adipose tissue macrophages (ATM) are a substantial component of adipose tissue. Here, beside their classical immune function, they uptake and process lipids therefore contributing to lipid metabolism. However, their functional relevance for thermogenic fat is poorly understood. In this project we aim to unravel the role of ATM lipid uptake and processing during activation of thermogenic fat. In particular, we will dissect ATM immune and metabolic function as well as the impact of ATM on adipocyte thermogenic function and on systemic energy metabolism.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 333: Brown and Beige Fat – Organ Crosstalk, Signaling and Energetics (BATenergy)
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Heads: Lidia Bosurgi, Ph.D.; Dr. Anna Worthmann