EXC 307:  Interdisciplinary Centre for Integrative Neuroscience (CIN)

Final Report Abstract

The Werner Reichardt Centre for Integrative Neuroscience (CIN) has been the joint platform of systems neuroscience in Tübingen since 2007. CIN members have been investigating the question how the brain generates its array of “higher level” functions like perception, memory, emotions, communication, movement – in sum functions that define human per-sonalities – and how they are impaired by disease. We have been guided by the conviction that only an integrative approach can provide the desired answers. Correspondingly, CIN research groups have worked on multiple levels, integrating research on molecules and genes, neurons and neuronal networks, as well as on behaviour and cognition. To this end, they have deployed a wide variety of methods: imaging, electrophysiology, behavioural stud-ies, theoretical modelling – implemented in vitro, in vivo and in silico, as appropriate. With the funding from the excellence initiative, the CIN has been able to set up and fill 6 pro-fessorships right from the start and to recruit altogether 20 junior research group leaders with tenure perspective. Seven of them were promoted to the rank of professor as a result of a rigorous evaluation. Furthermore, two senior professorships could be supported. The circle of CIN members, initially involving 25 principle investigators, grew over the years to about 90. Research of members was supported by “pool project” grants based on CIN intramural funding – small-scale and revolving around specific research questions – resulting in many publications, doctorates, and in quite a few cases in applications for larger scale external funding. Overall, the research output of CIN groups has been extremely respectable, not only in terms of quantity, but above all in terms of quality, with CIN publications typically placed among the 10% most impactful in their respective fields. In order to meet its responsibility towards the next generation, the CIN founded the Tübingen Graduate Training Centre (GTC) Neuroscience, compromising three complementary neuro-science graduate schools. The GTC provides training to 45 master students per year and has graduated a total of 300 doctoral students so far. A key measure of outreach and communication, the Neuroscience Lab for High School Students brought the lab experience to about 2,000 pupils and 200 teachers annually. With our long-standing international partners from Japan at NIPS (Okazaki) and Kyoto University the student and staff exchange is cur-rently planned to be expanded by a joint research programme. The CIN has become a major pillar of the Tübingen Neuro Campus (TNC, founded 2018), an alliance in which the CIN is complemented by several more clinically or theoretically oriented institutions, supporting conceptual and methodological exchange and interactions.

Link to the final report

https://dx.doi.org/10.2314/GBV:1697106641

Publications

• The coding of color, motion, and their conjunction in the human visual cortex. Curr Biol. 2009;19(3):177-83
  Seymour K, Clifford CW, Logothetis NK, Bartels A
  
• Decorrelated neuronal firing in cortical microcircuits. Science. 2010;327(5965):584-7
  Ecker AS, Berens P, Keliris GA, Bethge M, Logothetis NK, Tolias AS
  
• Discrimination of vibrotactile stimuli in the rat whisker system: behavior and neurometrics. Neuron. 2010;65(4):530-40
  Gerdjikov TV, Bergner CG, Stuttgen MC, Waiblinger C, Schwarz C
  
• Disrupting parietal function prolongs dominance durations in binocular rivalry. Curr Biol. 2010;20(23):2106-11
  Zaretskaya N, Thielscher A, Logothetis NK, Bartels A
  
• Evidence for a protein tether involved in somatic touch. EMBO J. 2010;29(4):855-67
  Hu J, Chiang LY, Koch M, Lewin GR
  
• Retinal processing: global players like it local. Curr Biol. 2010;20(11):R486-8
  Schubert T, Euler T
  
• Oscillatory synchronization in large-scale cortical networks predicts perception. Neuron. 2011;69(2):387-96
  Hipp JF, Engel AK, Siegel M
  
• The detection of visual contrast in the behaving mouse. J Neurosci. 2011;31(31):11351-61
  Busse L, Ayaz A, Dhruv NT, Katzner S, Saleem AB, Scholvinck ML, Zaharia AD, Carandini M
  
• A measure of my agency? Conscious Cogn. 2012;21(1):48-51; discussion 5-8
  Wong HY
  
• Channel noise from both slow adaptation currents and fast currents is required to explain spike-response variability in a sensory neuron. J Neurosci. 2012;32(48):17332-44
  Fisch K, Schwalger T, Lindner B, Herz AV, Benda J
  
• Spectral fingerprints of large-scale neuronal interactions. Nat Rev Neurosci. 2012;13(2):121-34
  Siegel M, Donner TH, Engel AK
  
• Visual motion responses in the posterior cingulate sulcus: a comparison to V5/MT and MST. Cereb Cortex. 2012;22(4):865-76
  Fischer E, Bulthoff HH, Logothetis NK, Bartels A
  
• A tale of two retinal domains: near-optimal sampling of achromatic contrasts in natural scenes through asymmetric photoreceptor distribution. Neuron. 2013;80(5):1206-17
  Baden T, Schubert T, Chang L, Wei T, Zaichuk M, Wissinger B, Euler T
  
• Alteration of visual perception prior to microsaccades. Neuron. 2013;77(4):775-86
  Hafed ZM
  
• Altered intrinsic neuronal interactions in the visual cortex of the blind. J Neurosci. 2013;33(43):17072-80
  Hawellek DJ, Schepers IM, Roeder B, Engel AK, Siegel M, Hipp JF
  
• Auditory closed-loop stimulation of the sleep slow oscillation enhances memory. Neuron. 2013;78(3):545-53
  Ngo HV, Martinetz T, Born J, Molle M
  
• Chromatic coding from cone-type unselective circuits in the mouse retina. Neuron. 2013;77(3):559-71
  Chang L, Breuninger T, Euler T
  
• Decoding the yellow of a gray banana. Curr Biol. 2013;23(22):2268-72
  Bannert MM, Bartels A
  
• Dissociation of reach-related and visual signals in the human superior colliculus. Neuroimage. 2013;82:61-7
  Himmelbach M, Linzenbold W, Ilg UJ
  
• Parietal cortex codes for egocentric space beyond the field of view. Curr Biol. 2013;23(2):177-82
  Schindler A, Bartels A
  
• Perceptual effects of stimulating V5/hMT+ during binocular rivalry are state specific. Curr Biol. 2013;23(20):R919-20
  Zaretskaya N, Bartels A
  
• Complementary roles for primate frontal and parietal cortex in guarding working memory from distractor stimuli. Neuron. 2014;83(1):226-37
  Jacob SN, Nieder A
  
• Effects of locomotion extend throughout the mouse early visual system. Curr Biol. 2014;24(24):2899-907
  Erisken S, Vaiceliunaite A, Jurjut O, Fiorini M, Katzner S, Busse L
  
• iPSC-derived neurons from GBA1-associated Parkinson's disease patients show autophagic defects and impaired calcium homeostasis. Nat Commun. 2014;5:4028
  Schondorf DC, Aureli M, McAllister FE, Hindley CJ, Mayer F, Schmid B, Sardi SP, Valsecchi M, Hoffmann S, Schwarz LK, Hedrich U, Berg D, Shihabuddin LS, Hu J, Pruszak J, Gygi SP, Sonnino S, Gasser T, Deleidi M
  
• Mirror representations innate versus determined by experience: a viewpoint from learning theory. Behav Brain Sci. 2014;37(2):201-2
  Giese MA
  
• Presynaptic GABAergic inhibition regulated by BDNF contributes to neuropathic pain induction. Nat Commun. 2014;5:5331
  Chen JT, Guo D, Campanelli D, Frattini F, Mayer F, Zhou L, Kuner R, Heppenstall PA, Knipper M, Hu J
  
• State dependence of noise correlations in macaque primary visual cortex. Neuron. 2014;82(1):235-48
  Ecker AS, Berens P, Cotton RJ, Subramaniyan M, Denfield GH, Cadwell CR, Smirnakis SM, Bethge M, Tolias AS
  
• Static frequency tuning accounts for changes in neural synchrony evoked by transient communication signals. J Neurophysiol. 2014;112(4): 752-65
  Walz H, Grewe J, Benda J
  
• A neural mechanism for timewindow separation resolves ambiguity of adaptive coding. PLoS Biol. 2015;13(3):e1002096
  Hildebrandt KJ, Ronacher B, Hennig RM, Benda J
  
• BOLD fMRI Correlation Reflects Frequency-Specific Neuronal Correlation. Curr Biol. 2015;25(10):1368-74
  Hipp JF, Siegel M
  
• Cortical information flow during flexible sensorimotor decisions. Science. 2015;348(6241):1352-5
  Siegel M, Buschman TJ, Miller EK
  
• Deletion of myosin VI causes slow retinal optic neuropathy and age-related macular degeneration (AMD)-relevant retinal phenotype. Cell Mol Life Sci. 2015;72(20):3953-69
  Schubert T, Gleiser C, Heiduschka P, Franz C, Nagel-Wolfrum K, Sahaboglu A, Weisschuh N, Eske G, Rohbock K, Rieger N, Paquet-Durand F, Wissinger B, Wolfrum U, Hirt B, Singer W, Ruttiger L, Zimmermann U, Knipper M
  
• Effects of an interleukin-1 receptor antagonist on human sleep, sleep-associated memory consolidation, and blood monocytes. Brain Behav Immun. 2015;47:178-85
  Schmidt EM, Linz B, Diekelmann S, Besedovsky L, Lange T, Born J
  
• Membrane stiffening by STOML3 facilitates mechanosensation in sensory neurons. Nat Commun. 2015;6:8512
  Qi Y, Andolfi L, Frattini F, Mayer F, Lazzarino M, Hu J
  
• Neuronal Response Gain Enhancement prior to Microsaccades. Curr Biol. 2015;25(16):2065-74
  Chen CY, Ignashchenkova A, Thier P, Hafed ZM
  
• Neurons selective to the number of visual items in the corvid songbird endbrain. Proc Natl Acad Sci USA. 2015;112(25):7827-32
  Ditz HM, Nieder A
  
• Open Labware: 3-D printing your own lab equipment. PLoS Biol. 2015;13(3):e1002086
  Baden T, Chagas AM, Gage GJ, Marzullo TC, Prieto-Godino LL, Euler T
  
• Oscillatory entrainment of the motor cortical network during motor imagery is modulated by the feedback modality. Neuroimage. 2015;111:1-11
  Vukelic M, Gharabaghi A
  
• Principles of connectivity among morphologically defined cell types in adult neocortex. Science. 2015;350(6264):aac9462
  Jiang X, Shen S, Cadwell CR, Berens P, Sinz F, Ecker AS, Patel S, Tolias AS
  
• Retinal output changes qualitatively with every change in ambient illuminance. Nat Neurosci. 2015;18(1):66-74
  Tikidji-Hamburyan A, Reinhard K, Seitter H, Hovhannisyan A, Procyk CA, Allen AE, Schenk M, Lucas RJ, Munch TA
  
• Spine loss in primary somatosensory cortex during trace eyeblink conditioning. J Neurosci. 2015;35(9):3772-81
  Joachimsthaler B, Brugger D, Skodras A, Schwarz C
  
• Vibrotactile discrimination in the rat whisker system is based on neuronal coding of instantaneous kinematic cues. Cereb Cortex. 2015;25(4):1093-106
  Waiblinger C, Brugger D, Schwarz C
  
• A human brain network derived from coma-causing brainstem lesions. Neurology. 2016;87(23):2427-34
  Fischer DB, Boes AD, Demertzi A, Evrard HC, Laureys S, Edlow BL, Liu H, Saper CB, Pascual-Leone A, Fox MD, Geerling JC
  
• Anatomical organization of presubicular head-direction circuits. Elife. 2016;5
  Preston-Ferrer P, Coletta S, Frey M, Burgalossi A
  
• BCM: toolkit for Bayesian analysis of Computational Models using samplers. BMC Syst Biol. 2016;10(1):100
  Thijssen B, Dijkstra TM, Heskes T, Wessels LF
  
• Benchmarking Spike Rate Inference in Population Calcium Imaging. Neuron. 2016;90(3):471-82
  Theis L, Berens P, Froudarakis E, Reimer J, Roman Roson M, Baden T, Euler T, Tolias AS, Bethge M
  
• Connectivity map of bipolar cells and photoreceptors in the mouse retina. Elife. 2016;5
  Behrens C, Schubert T, Haverkamp S, Euler T, Berens P
  
• Emotions and Decisions: Beyond Conceptual Vagueness and the Rationality Muddle. Perspect Psychol Sci. 2016;11(1):101-16
  Volz KG, Hertwig R
  
• Face Recognition: Canonical Mechanisms at Multiple Timescales. Curr Biol. 2016;26(13):R534-R7
  Giese MA
  
• Feedforward and feedback sources of choice probability in neural population responses. Curr Opin Neurobiol. 2016;37:126-32
  Cumming BG, Nienborg H
  
• Identification of causal relations in neuroimaging data with latent confounders: An instrumental variable approach. Neuroimage. 2016;125:825-33
  Grosse-Wentrup M, Janzing D, Siegel M, Scholkopf B
  
• Mirror Neurons in Monkey Premotor Area F5 Show Tuning for Critical Features of Visual Causality Perception. Curr Biol. 2016;26(22):3077-82
  Caggiano V, Fleischer F, Pomper JK, Giese MA, Thier P
  
• Motor cortex activity predicts response alternation during sensorimotor decisions. Nat Commun. 2016;7:13098
  Pape AA, Siegel M
  
• Physiological processes non-linearly affect electrophysiological recordings during transcranial electric stimulation. Neuroimage. 2016;140:99-109
  Noury N, Hipp JF, Siegel M
  
• Priming Spatial Activity by Single-Cell Stimulation in the Dentate Gyrus of Freely Moving Rats. Curr Biol. 2016;26(4):536-41. Epub 2016/02/09
  Diamantaki M, Frey M, Preston-Ferrer P, Burgalossi A
  
• Sharper, Stronger, Faster Upper Visual Field Representation in Primate Superior Colliculus. Curr Biol. 2016;26(13):1647-58
  Hafed ZM, Chen CY
  
• Sleep-Stage-Specific Regulation of Cortical Excitation and Inhibition. Curr Biol. 2016;26(20):2739-49
  Niethard N, Hasegawa M, Itokazu T, Oyanedel CN, Born J, Sato TR
  
• Sparse activity of identified dentate granule cells during spatial exploration. Elife. 2016;5
  Diamantaki M, Frey M, Berens P, Preston-Ferrer P, Burgalossi A
  
• The Default Mode Network Differentiates Biological From Non-Biological Motion. Cereb Cortex. 2016;26(1):234-45
  Dayan E, Sella I, Mukovskiy A, Douek Y, Giese MA, Malach R, Flash T
  
• The functional diversity of retinal ganglion cells in the mouse. Nature. 2016;529(7586):345-50
  Baden T, Berens P, Franke K, Roman Roson M, Bethge M, Euler T
  
• The neuronal code for number. Nat Rev Neurosci. 2016;17(6):366-82
  Nieder A
  
• The Slip Hypothesis: Tactile Perception and its Neuronal Bases. Trends Neurosci. 2016;39(7):449-62
  Schwarz C
  
• Decision-Related Activity in Macaque V2 for Fine Disparity Discrimination Is Not Compatible with Optimal Linear Readout. J Neurosci. 2017;37(3):715-25
  Clery S, Cumming BG, Nienborg H
  
• Inhibition decorrelates visual feature representations in the inner retina. Nature. 2017;542(7642):439-44
  Franke K, Berens P, Schubert T, Bethge M, Euler T, Baden T
  
• Limiting parental feedback disrupts vocal development in marmoset monkeys. Nat Commun. 2017;8:14046
  Gultekin YB, Hage SR
  
• Local Signals in Mouse Horizontal Cell Dendrites. Curr Biol. 2017;27(23):3603-15 e5
  Chapot CA, Behrens C, Rogerson LE, Baden T, Pop S, Berens P, Euler T, Schubert T
  
• Rods progressively escape saturation to drive visual responses in daylight conditions. Nat Commun. 2017;8(1):1813
  Tikidji-Hamburyan A, Reinhard K, Storchi R, Dietter J, Seitter H, Davis KE, Idrees S, Mutter M, Walmsley L, Bedford RA, Ueffing M, Ala-Laurila P, Brown TM, Lucas RJ, Munch TA
  
• Safety and efficacy of long-term home treatment with transcranial direct current stimulation (tDCS) in a case of multimodal hallucinations. Brain Stimul. 2017;10(4):873-4
  Schwippel T, Wasserka B, Fallgatter AJ, Plewnia C
  
• Serotonin Decreases the Gain of Visual Responses in Awake Macaque V1. J Neurosci. 2017;37(47):11390-405
  Seillier L, Lorenz C, Kawaguchi K, Ott T, Nieder A, Pourriahi P, Nienborg H
  
• Synchronous spikes are necessary but not sufficient for a synchrony code in populations of spiking neurons. Proc Natl Acad Sci U S A. 2017;114(10):E1977-E85
  Grewe J, Kruscha A, Lindner B, Benda J
  
• The Descending Diencephalic Dopamine System Is Tuned to Sensory Stimuli. Curr Biol. 2017;27(3):318-33
  Reinig S, Driever W, Arrenberg AB
  
• The euro100 lab: A 3D-printable open-source platform for fluorescence microscopy, optogenetics, and accurate temperature control during behaviour of zebrafish, Drosophila, and Caenorhabditis elegans. PLoS Biol. 2017;15(7):e2002702
  Maia Chagas A, Prieto-Godino LL, Arrenberg AB, Baden T
  
• Analyzing EEG and MEG signals recorded during tES, a reply. Neuroimage. 2018;167:53-61
  Noury N, Siegel M
  
• Can Serial Dependencies in Choices and Neural Activity Explain Choice Probabilities? J Neurosci. 2018;38(14):3495-506
  Lueckmann JM, Macke JH, Nienborg H
  
• Cortical circuit activity underlying sleep slow oscillations and spindles. Proc Natl Acad Sci USA. 2018;115(39):E9220-E9
  Niethard N, Ngo HV, Ehrlich I, Born J
  
• Cortical modulation of sensory flow during active touch in the rat whisker system. Nat Commun. 2018;9(1):3907
  Chakrabarti S, Schwarz C
  
• DeepLabCut: markerless pose estimation of user-defined body parts with deep learning. Nat Neurosci. 2018;21(9):1281-9
  Mathis A, Mamidanna P, Cury KM, Abe T, Murthy VN, Mathis MW, Bethge M
  
• Evoking and tracking zebrafish eye movement in multiple larvae with ZebEyeTrack. Nat Protoc. 2018;13(7):1539-68
  Dehmelt FA, von Daranyi A, Leyden C, Arrenberg AB
  
• Fast track to the neocortex: A memory engram in the posterior parietal cortex. Science. 2018;362(6418):1045-8
  Brodt S, Gais S, Beck J, Erb M, Scheffler K, Schonauer M
  
• Genetic Code Expansion- and Click Chemistry-Based Site-Specific Protein Labeling for Intracellular DNA-PAINT Imaging. Methods Mol Biol. 2018;1728:279-95
  Nikic-Spiegel I
  
• Limiting parental interaction during vocal development affects acoustic call structure in marmoset monkeys. Sci Adv. 2018;4(4):eaar4012
  Gultekin YB, Hage SR
  
• LISA improves statistical analysis for fMRI. Nat Commun. 2018;9(1):4014
  Lohmann G, Stelzer J, Lacosse E, Kumar VJ, Mueller K, Kuehn E, Grodd W, Scheffler K
  
• Manipulating Hippocampal Place Cell Activity by Single-Cell Stimulation in Freely Moving Mice. Cell Rep. 2018;23(1):32-8
  Diamantaki M, Coletta S, Nasr K, Zeraati R, Laturnus S, Berens P, Preston-Ferrer P, Burgalossi A.
  
• Spatial frequency sensitivity in macaque midbrain. Nat Commun. 2018;9(1):2852
  Chen CY, Sonnenberg L, Weller S, Witschel T, Hafed ZM
  
• Statistics of Natural Communication Signals Observed in the Wild Identify Important Yet Neglected Stimulus Regimes in Weakly Electric Fish. J Neurosci. 2018;38(24):5456-65
  Henninger J, Krahe R, Kirschbaum F, Grewe J, Benda J
  
• Streamlined sensory motor communication through cortical reciprocal connectivity in a visually guided eye movement task. Nat Commun. 2018;9(1):338
  Itokazu T, Hasegawa M, Kimura R, Osaki H, Albrecht UR, Sohya K, Chakrabarti S, Itoh H, Ito T, Sato TK, Sato TR
  
• Structuring of Abstract Working Memory Content by Fronto-parietal Synchrony in Primate Cortex. Neuron. 2018;99(3):588-97 e5
  Jacob SN, Hahnke D, Nieder A
  
• Testing the Efficacy of Single-Cell Stimulation in Biasing Presubicular Head Direction Activity. J Neurosci. 2018;38(13):3287-302
  Coletta S, Frey M, Nasr K, Preston-Ferrer P, Burgalossi A
  
• The hippocampus is crucial for forming non-hippocampal long-term memory during sleep. Nature. 2018;564(7734):109-13
  Sawangjit A, Oyanedel CN, Niethard N, Salazar C, Born J, Inostroza M
  
• The Lombard Effect: From Acoustics to Neural Mechanisms. Trends Neurosci. 2018;41(12):938-49
  Luo J, Hage SR, Moss CF
  
• Two Ways to Facial Expression Recognition? Motor and Visual Information Have Different Effects on Facial Expression Recognition. Psychol Sci. 2018;29(8):1257-69
  de la Rosa S, Fademrecht L, Bulthoff HH, Giese MA, Curio C
  
• Ultra-Slow Single-Vessel BOLD and CBV-Based fMRI Spatiotemporal Dynamics and Thier Correlation with Neuronal Intracellular Calcium Signals. Neuron. 2018;97(4):925-39 e5
  He Y, Wang M, Chen X, Pohmann R, Polimeni JR, Scheffler K, Rosen BR, Kleinfeld D, Yu X
  
• Back to baseline: sleep recalibrates synapses. Nat Neurosci. 2019;22(2):149-51
  Niethard N, Born J
  
• Cognitive control of complex motor behavior in marmoset monkeys. Nat Commun. 2019;10(1):3796
  Pomberger T, Risueno-Segovia C, Gultekin YB, Dohmen D, Hage SR
  
• High throughput, rapid receptive field estimation for global motion sensitive neurons using a contiguous motion noise stimulus. J Neurosci Methods. 2019;326:108366
  Zhang Y, Arrenberg AB
  
• Monkey EEG links neuronal color and motion information across species and scales. Elife. 2019;8
  Sandhaeger F, von Nicolai C, Miller EK, Siegel M
  
• Mouse dLGN Receives Functional Input from a Diverse Population of Retinal Ganglion Cells with Limited Convergence. Neuron. 2019;102(2):462-76 e8
  Roman Roson M, Bauer Y, Kotkat AH, Berens P, Euler T, Busse L
  
• Number detectors spontaneously emerge in a deep neural network designed for visual object recognition. Sci Adv. 2019;5(5):eaav7903
  Nasr K, Viswanathan P, Nieder A
  
• Selective processing of all rotational and translational optic flow directions in the zebrafish pretectum and tectum. BMC Biol. 2019;17(1):29
  Wang K, Hinz J, Haikala V, Reiff DF, Arrenberg AB
  
• The Foveal Visual Representation of the Primate Superior Colliculus. Curr Biol. 2019;29(13):2109-19 e7
  Chen CY, Hoffmann KP, Distler C, Hafed ZM