Predicting therapy response and relapse of aggressive B cell lymphomas (C03*)

Subject Area Evolutionary Cell and Developmental Biology (Zoology)
Term since 2022
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 325931972
 

Project Description

Project C3 will investigate molecular mechanisms that allow the diffuse large B cell lymphomas (DLBCL) to escape chemo-immune therapies. We will combine genotyping with spatial analysis of cancer tissues by new imaging and machine-learning techniques. We will correlate genetic determinants of tumor escape with tumor micro-environment data, including density and spatial distribution of immune cells, to map evolutionary mechanisms of treatment evasion.
DFG Programme Collaborative Research Centres
Subproject of SFB 1310:  Predictability in Evolution
Applicant Institution Universität zu Köln
Project Heads Professorin Dr. Katarzyna Bozek, since 1/2022; Professor Dr. Reinhard Büttner, since 1/2022