Modulation of the macrophage/adipocyte interface in age-related insulin resistance by the Glucocorticoid Receptor
(C05)
Subject Area
Endocrinology, Diabetology, Metabolism
Biophysics
Term
since 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 450627322
The glucocorticoid receptor (GR) promotes insulin resistance (IR) in middle-aged mice through its action in adipocytes, but protects against insulin resistance through its expression in macrophages and in adipocytes of old mice. We now aim to decipher the dynamics of the cellular macrophage/adipocyte interface and its interplay with the molecular GR/cofactor interface by performing biochemical and single-molecule studies of GR-dependent signatures in primary cells of transgenic rodents and aged humans.
DFG Programme
Collaborative Research Centres
