Clearance of Senescent Cells by Rejuvenation of the Aged Immune System (B04)

• Subject Area: Biogerontology and Geriatric Medicine
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 450627322

We focus on the role of aging-associated immune remodeling for the regulation of senescent cell accumulation in tissues of old mice. For it, we study if (and how) young, old and rejuvenated old immune systems, de novo generated by hematopoietic stem cells in transplanted RAG1-/- mice, (i) reduce the natural senescent-cell tissue burden and SASP and (ii) eliminate transplanted senescent mouse lung fibroblasts. In murine and human in vitro co-cultures, we will determine the interactions between innate-like CD8 T cells and senescent fibroblasts.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1506: Aging at Interfaces
• International Connection: Israel
• Applicant Institution: Universität Ulm
• Project Heads: Professor Dr. Valery Krizhanovsky, Ph.D.; Professor Dr. Reinhold Schirmbeck