Loss of translational accuracy in aging and aging-associated disease (A06)

• Subject Area: Biogerontology and Geriatric Medicine
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 450627322

The skin at the interface of body and environment is subject to aging processes and mirrors systemic aging. In skin cells we plan to study the contribution of the protein synthesis apparatus to cellular and tissue aging. We intend to ask the question if a fading of the accuracy of the protein translation process at the ribosome, recently identified in premature-aging childhood disorders, also characterizes intrinsic aging. Does this pathomechanism explain the loss of proteostasis in neurodegenerative disease like Parkinson´s disease? Interventional strategies will be tested in skin organoid models.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1506: Aging at Interfaces
• Applicant Institution: Universität Ulm
• Project Head: Privatdozent Dr. Sebastian Iben