Das Notch/NF-KB Wechselspiel an der alternden Synapse: Die Rolle des Inflammaging beim kognitiven Verfall
(A05)
Fachliche Zuordnung
Biochemie
Molekulare Biologie und Physiologie von Nerven- und Gliazellen
Förderung
Förderung seit 2022
Projektkennung
Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 450627322
Project A05 addresses the hypothesis that brain inflammaging is critically regulated by Notch/NF-KB crosstalk signaling which can promote synapse aging via cell-intrinsic and paracrine mechanisms finally resulting in motoric and cognitive decline. For this, structural and functional consequences at synaptic interfaces built up by neurons and different types of glia cells in young and old mice will be characterized using conditional transgenic systems mimicking brain inflammaging and allowing cell-type-specific Notch/NF-KB modulation.
DFG-Verfahren
Sonderforschungsbereiche
