Metabolic reprogramming steered by ISGylation in HFpEF (A08)

• Subject Area: Biochemistry ; Endocrinology, Diabetology, Metabolism ; Cardiology, Angiology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 437531118

Obesity is a major contributing feature of HFpEF and known to stimulate chronic low-grade inflammation. Cells respond to inflammatory stimuli with reprogramming of their posttranslational modification pathways and activation of protein ISGylation. This project pursues the hypothesis that chronic inflammation in cardiometabolic HFpEF provokes a metabolic adaptation of the heart possibly through the activation of the ISG15 machinery. By combining system biochemistry with computational metabolic modeling, this project will investigate the metabolic alterations occurring in the heart and define how the ISG15 system intersects in the regulation of cardiac metabolic capability in HFpEF.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1470: Multilevel mechanistic characterisation of Heart Failure with Preserved Ejection Fraction - Towards a novel classification of HFpEF for targeted therapies
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Heads: Professorin Dr. Antje Beling; Privatdozent Dr. Nikolaus Berndt