Role of sex hormones on microbiome, immunity, and coronary microvascular dysfunction and rarefication in experimental HFpEF (A05)

• Subject Area: Endocrinology, Diabetology, Metabolism ; Immunology ; Cardiology, Angiology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 437531118

HFpEF is more often diagnosed in women, especially post menopause, but who on average face less effective care. We hypothesize sex differentially in HFpEF reflect 1) sex steroid impact directly or indirectly on gut microbiome, circulating metabolites, or immune system; in turn acting through 2) coronary microvascular dysfunction. Applying multi-omics technologies to animal models of HFpEF where endocrine sex can be manipulated, we will test this hypothesis and determine its specific microbial, immune and molecular drivers. Findings will be projected into the human setting by integrative and comparative analysis of host-microbiome data from this CRC and other sources.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1470: Multilevel mechanistic characterisation of Heart Failure with Preserved Ejection Fraction - Towards a novel classification of HFpEF for targeted therapies
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Heads: Professor Dr. Ralf Dechend; Professorin Dr. Sofia Forslund-Startceva