Control and Activity of the Streptomyces Spore Wall Synthesizing Complex (SSSC) (A02)

• Subject Area: Parasitology and Biology of Tropical Infectious Disease Pathogens
• Term: from 2007 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 32152271

During the life cycle of antibiotic producing streptomycetes the hyphae are septated into chains of more than 50 spores in a highly synchronized manner. The Streptomyces spore wall synthesizing complex SSSC, which resembles the elongasome of rod-shaped bacteria has a key role in this process. We want to elucidate how the Streptomyces spore wall synthesizing complex SSSC achieves the synthesis of peptidoglycan and anionic glycopolymers and how protein phosphorylation controls the coordination of the SSSCs.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 766: The Bacterial Cell Envelope: Structure, Function and Infection Interface
• Applicant Institution: Eberhard Karls Universität Tübingen
• Project Heads: Dr. Günther Muth; Professor Dr. Wolfgang Wohlleben