Project Details
Projekt
Natural immune regulation in transplantation (A05)
Subject Area
Immunology
Term
from 2007 to 2019
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 24899777
Several groups within CRC738 investigate the role of Foxp3+ regulatory T-cells, but NK cells also play an important role in the balance of immunity and tolerance. Results from A5 demonstrated that mesenchymal stem cells can suppress NK effector function and even induce immune regulatory CD73 on their surface, but coculture with immunostimulatory slan-dendritic cells (DCs) strongly activated NK cells. Therefore, it seems that NK cells are able to amplify immunogenic as well as tolerogenic signals, depending on their immunological microenvironment. Therefore, A5 will investigate the role of slan-DCs early after stem cell transplantation. Finally, project A5 was the first to describe allomorphic antibodies against mismatched NK cell receptors (NKC and LRC) after liver and kidney transplantation using samples from Z2. They will investigate the prevalence and functional and clinical consequence of alloantibodies against these NK cell receptors.
DFG Programme
Collaborative Research Centres
Applicant Institution
Medizinische Hochschule Hannover
Project Heads
Professor Dr. Roland Jacobs; Professor Dr. Reinhold Ernst Schmidt (†)
