high resolution GC-EI-MSMS instrument

• Subject Area: Basic Research in Biology and Medicine ; Analytical Chemistry
• Term: Funded in 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 467386044

Mass spectrometry is a cross-sectional technology that plays a key role in chemical, biochemical and molecular biological research and teaching. Representatives of the Institute of Chemistry and the Institute of Biochemistry and Biology of the University of Potsdam have joined forces and combined the urgently needed replacements and a new acquisition of individual mass spectrometry instruments with the establishment of a cross-institute MS analytics center. Our aim is to strengthen synergy effects and to share and expand analytical expertise at the University of Potsdam. Further, we intend to coordinate the use of various analytical techniques, to enhance the overall capacity and to prevent repair bottlenecks. With main use in the Institute of Chemistry, here, we apply for a GC-EI-MSMS instrument for the analysis of small, easily vaporizable molecules to replace the old GC-EI mass spectrometer, which is prone to repair. The instrument will be used to perform high-resolution EI/CI measurements to determine accurate masses. The new possibility of recording MS/MS spectra for unambiguous characterization of the analytes should greatly expand the range of applications for specific research work in the field of tandem mass spectrometry. As part of the package proposal, the following additional equipment is also requested: 1) an LC-ESI-IMS-MSMS instrument for dissolved samples (replacement proposal and expansion to include the previously missing ion mobility spectrometry/Institute of Chemistry), 2) a MALDI-MSMS instrument into which samples are applied in crystalline matrix (replacement proposal/Institute of Biochemistry and Biology), and 3) an ultra-high resolution LC-ESI-Orbitrap-MSMS instrument for dissolved samples.Numerous groups from both institutes will benefit from higher performance and versatility of the instruments (including IMS and ultra-high resolution) as well as the significantly increased sample capacity and will be able to advance internationally competitive research projects.

• DFG Programme: Major Research Instrumentation
• Major Instrumentation: Hochauflösendes GC-EI-MSMS-System
• Instrumentation Group: 1700 Massenspektrometer
• Applicant Institution: Universität Potsdam
• Leader: Professor Dr. Heiko Möller