The role of chromatin in the establishment of inter-chromosomal DNA-DNA interactions (A33*)

• Subject Area: General Genetics and Functional Genome Biology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 213249687

Inter-chromosomal interactions are essential for gene regulation in numerous biological systems including the mutually exclusive antigen expression in African Trypanosomes. Yet, very little is known about the mechanisms leading to the establishment and maintenance of such interactions. The goal of the work proposed here is to combine different live-cell imaging approaches and proteomics-based chromatin analyses to determine the molecular factors responsible for the establishment and maintenance of distinct inter-chromosomal DNA-DNA interactions in Trypanosoma brucei.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1064: Chromatin Dynamics
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Head: Professor Dr. Tim Nicolai Siegel