Wnt pathway specificity in niche – stem cell control (A08*)

• Subject Area: Developmental Biology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 331351713

Wnt signaling is critical for stem cell development and homeostasis. However, it is still underexplored how Wnt pathways control different stem cell populations within one tissue in a cell-type specific manner. We will study two stem cell niches in Drosophila to elucidate context-dependent Wnt input and output codes influenced by cross-talk with other signaling pathways at the single cell level. Comparison and functional analysis of the Wnt code will be instrumental in understanding the basic principles as well as the particularities of Wnt encoded specificity in different stem cell types.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1324: Mechanisms and functions of Wnt signaling
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Heads: Dr. Josephine Bageritz; Professorin Dr. Ingrid Lohmann