Project Details
Projekt
Targeting T cell-intrinsic negative regulators to enhance the therapeutic potential of adoptive T cell therapy (C03)
Subject Area
Immunology
Term
since 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 452881907
The goal of this project is to identify and validate genes that negatively regulate antigen-specific T cell function in a cell-intrinsic fashion, aiming at enhancing the activity of low-avidity T cells for adoptive T cell therapy upon perturbation of these targets. On the one hand, we will address the hypothesis that T cell-intrinsic cGAS-STING signaling exerts a negative effect on T cell activity. On the other hand, we will systematically validate a list of candidate genes for their impact on the functional activity of CD8+ T cells and also conduct a genome-wide, unbiased screen to identify negative regulators of T cell activation in a setting of low affinity, antigen-specific activation of T cells.
DFG Programme
CRC/Transregios
Applicant Institution
Technische Universität München (TUM)
Project Head
Professor Dr. Veit Hornung
